Effect of from the Sustained Hyperg Isolated Perfused lycemia on the Rat Pancreas Release of Insulin
نویسنده
چکیده
The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24 h and 48 h hyperglycemic rats , the increase i n the amount of insulin released was reduced in response to glucose challenge , but was unchanged in relation to arginine challenge. In 48 h hyperglycemic rats insulin secretion after glucagon challenge was preserved. It was concluded that hyperglycemia itself makes the pancreatic B-cell selectively insensitive to glucose.
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